Marcus Program in Precision Medicine Innovation

2017 submissions are closed

Awards announcement will be made by April 15, 2017

Awards publicly announced at the Annual Marcus Symposium on April 18, 2017

 

Annual Marcus Symposium

The Marcus Program in Precision Medicine Innovation (MPPMI), in collaboration with the University Development and Alumni Relations, UCSF Precision Medicine Platform and the Research Development Office's Team Science for Research Innovation Program (TSRIP), is hosting the Annual Marcus Symposium to celebrate the completion of the 2016 cycle of the Marcus Program in Precision Medicine Innovation Award. A selection of current awardees will give project updates and we will announce the 2017 cycle awardees at the event on Tuesday, April 18, 2017 from 3:00 – 6:00 pm on the Mission Bay Campus. For more information, please contact Page Sorensen.

George and Judy Marcus Awards

Marcus Program in Precision Medicine Innovation

2017 Call for Proposals

The Marcus Program in Precision Medicine Innovation (MPPMI) seeks to fuel innovation in precision medicine by fostering creative, high risk, high impact team science projects anchored in basic science and extending into the precision medicine continuum toward improved patient outcomes. See MPPMI Program Overview on the program website.

The MPPMI invites proposals for our 2017 funding in two award categories, Seeding Bold Ideas, and Transformative Integrated Research. Each category:

  • supports translational precision medicine research with a strong basic science core.
  • requires two or more co-PIs: at least one a basic scientist, and at least one a clinical, social/behavioral or population scientist; either existing or newly formed teams may apply.
  • seeks high-risk thinking or approaches that will likely yield explicit “deliverables” (including discovery that the idea was wrong) after one year.

Marcus Program Seeding Bold Ideas Award (MP-SBI)

  • Up to $75,000 for one year; eligible to compete for up to $400,000 in year two, if funds are available
  • SBI awards enable initial exploration of untested concepts or hypotheses with great potential impact
  • Up to four awards granted

Marcus Program Transformative Integrated Research Award (MP-TIR)

  • Up to $400,000 for one year; eligible to compete for up to $400,000 in year two, if funds are available
  • TIR awards support new directions for established basic science-driven translational studies
  • Up to three awards granted

    Submissions are closed; 2017 proposals are in review

    See MPPMI Call for Proposals (attached) for eligibility, proposal instructions, deadlines, criteria and selection process.
     

    Call for Proposals Announced

    January 3, 2017

    Proposal Application Deadline

    February 21, 2017

    Announcement of Awards

    April 15, 2017 (target funding start-May 1)

    Project Timeline

    1 year

Marcus Mixer: A Networking Event for the Marcus Program (MPPMI)

To foster a pipeline of new ideas and novel collaborations, the Marcus Program in Precision Medicine Innovation (MPPMI), in collaboration with the UCSF Precision Medicine Platform and the Research Development Office's Team Science for Research Innovation Program (TSRIP), is hosting a mixer to promote creative networking between scientists in basic research areas and those in clinical, social/behavioral or population research areas.

This event will take place on Thursday, October 13th, 2016 from 3:30-5:30pm on the Mission Bay Campus. The agenda includes an afternoon of innovation-sparking lightning talks followed by time to mingle and share bold ideas with colleagues. Learn more here.

George and Judy Marcus Awards

Inaugural Funding Cycle Awardees Announced!

The Marcus Program in Precision Medicine Innovation is pleased to announce the results of the inaugural call for innovative collaborative project proposals for the Seeding Bold Ideas and Transformative Integrated Research Initiatives. We received a total of 45 outstanding, creative, and potentially transformative trans-disciplinary research proposals from 135 faculty across UCSF. 25 cross-disciplinary teams submitted proposals to the Seeding Bold Ideas (SBI) Initiative and 20 teams submitted to the Transformative Integrated Research (TIR) Initiative.

A committee of researchers representing basic, clinical, and social/behavioral sciences reviewed, discussed, and selected 8 SBI projects and 4 TIR projects for funding.

The awardees for the 2016 Seeding Bold Ideas (SBI) Initiative are:

Team

Proposal Title

Joaquin Anguera, PhD   
Elysa Marco, MD
Adam Gazzaley, MD/PhD
Jyoti Mishra, PhD
Melina Uncapher, PhD

A Real-world, Real-time Mental Health Assessment

Mallar Bhattacharya, MD
Nirav Bhakta, MD
Adam Abate, PhD

Microfluidic droplet capture for gene expression analysis of airway smooth muscle in asthma

Trever Bivona, MD/PhD 
James Fraser, PhD

Systematic transformation of disease-driving genetic mutations into druggable therapeutic targets

Lindsey Criswell, MD/MPH/DSc;                              
Alexander Marson, MD/PhD

Creating a precision medicine approach for treatment response and outcome in rheumatoid arthritis

John Fahy, MD/MSc
Stephen Lazarus, MD
Brett Elicker, MD
Travis Henry, MD

Image-based precision mucolytic treatment for asthma

Robert Judson, PhD
Maria Wei, MD/PhD
Dexter Hadley, MD/PhD

An Integrated Nevus Risk Assessment Tool: predictive potential of RNA profiling and serial imaging

Pui-Yan Kwok, MD/PhD
Joseph Shieh, MD/PhD

Genome-wide structural variation analysis by novel sequencing and mapping technologies

Peter Walter, PhD
Jonathan Weissman, PhD
Susanna Rosi, PhD
Mervyn Maze, MD
Trever Bivona, MD/PhD
Jason Gestwicki, PhD   

Mapping and manipulating the proteostasis network in normal biology and disease

 

The awardees for the 2016 Transformative Integrated Research (TIR) Initiative are:

Team

Proposal Title

Trever Bivona, MD/PhD
Matt Thomson, PhD
Enhancing precision oncology via single-cell dissection of lung cancer pathogenesis and targeted therapy resistance
Joseph DeRisi, PhD
Samuel Pleasure, MD/PhD
Precision Diagnosis of Autoantibody Mediated Encephalitis
Nevan Krogan, PhD
Jennifer Grandis, MD

Identification of targetable signaling networks that mediate therapeutic resistance in head and neck cancer

 

Elliott Sherr, MD/PhD
Pratik Mukharjee, MD/PhD
Srikantan Nagarajan, PhD
Alma Burlingame, PhD
Deep endophenotyping in autism: Proteomics and Brain Imaging

 

Program Overview

The Marcus Program in Precision Medicine Innovation (MPPMI) seeks to fuel innovation in precision medicine by fostering creative, high risk, high impact team science projects anchored in basic science and extending into the precision medicine continuum toward improved patient outcomes.

Precision medicine aims to harness vast amounts of biological and biomedical data– from basic molecular research to clinical, environmental, socioeconomic and mobile lifestyle data – and use it to define biological processes and disease mechanisms, to understand why different individuals respond differently to treatments, and to help guide more precise, predictive and preventative medicine.

$4 million has been generously provided by George and Judy Marcus to drive innovative and collaborative efforts between basic researchers and clinical or social/behavioral/population scientists, which are essential to making precision medicine a reality. The MPPMI will advance precision medicine at UCSF through events that actively motivate and foster collaborations, and through direct funding of innovative research projects.

Funding Innovation:

The MPPMI invites proposals for funding in two award categories, Seeding Bold Ideas, and Transformative Integrated Research. Each category:

  • supports translational precision medicine research with a strong basic science core.
  • requires two or more co-PIs: at least one a basic scientist, and at least one a clinical, social/behavioral or population scientist; either existing or newly formed teams may apply.
  • seeks high-risk thinking or approaches that will likely yield explicit “deliverables” (including discovery that the idea was wrong) after one year.

Marcus Program Seeding Bold Ideas Award (MP-SBI)

  • Up to $75,000 for one year; eligible to compete for up to $400,000 in year two
  • SBI awards enable initial exploration of untested concepts or hypotheses with great potential impact

Marcus Program Transformative Integrated Research Award (MP-TIR)

  • Up to $400,000 for one year; eligible to compete for up to $400,000 in year two
  • TIR awards support new directions for established basic science-driven translational studies

(Funding Call: no longer accepting application for 2016)

See MPPMI Call for Proposals (attached) for eligibility, proposal instructions, deadlines, criteria and selection process.

 

Fostering Collaborations:

To foster a pipeline of bold ideas and novel collaborations, the MPPMI will actively promote creative networking between researchers in basic science and clinical, social/behavioral or population sciences.

  • Written Progress Reports: At the end of each award period, teams will submit a brief progress report; reports will be collected as an annual MPPMI summary.
  • Annual Workshop: Awardee presentations mixed with networking opportunities (e.g., topical roundtables) will be held at the end of each award period to showcase progress and facilitate new collaborations.
  • Networking events: MPPMI will host 1-2 networking events to foster collaborations, e.g., speed-networking or collaboratory meet-ups;

Program Announced:

December 21, 2015

Program Informational events:

January 11 and 12, 2016

Proposal Application Deadline:

February 8, 2016

Announcement of Awards:

February 22, 2016

Project Timeline:

1 year, plus competition for year 2 funding