George and Judy Marcus Awards
Marcus Program in Precision Medicine Innovation
2022 Awardees
The Marcus Program in Precision Medicine Innovation is pleased to announce the results of the 2022 cycle for innovative collaborative project proposals for the following grant mechanisms: Transformative Integrated Research (TIR), Seeding Bold Ideas (SBI), Ethical-Legal-Social Implications (ELSI) in Precision Medicine and a brand-new Inclusion-Diversity-Equity-Anti-Racism (IDEA) in Precision Medicine. We received a total of 41 excellent and potentially transformative trans-disciplinary research proposals from faculty across UCSF: 4 cross-disciplinary teams submitted proposals to the SBI Initiative, 23 teams submitted to the TIR Initiative, 8 teams submitted to ELSI Initiative and 6 teams submitted to IDEA Initiative.
A committee of ~25 researchers representing basic, clinical, computational health, and population health, and social/behavioral sciences reviewed, discussed, and selected 5 TIR, 1 SBI, 2 ELSI and 2 IDEA proposals for funding, distributing over $1.8M dollars.
In addition, this cycle we continued two funding supplement initiatives in support of inclusive excellence. The first program provides a supplement for awarded research projects involving human subjects to receive a patient and community consultation through the CTSI Community Engagement Program regarding their proposed study. This CTSI service was created to provide an easily accessible and efficient mechanism for UCSF researchers to obtain patient and community stakeholder input for their research projects. Nine awarded projects are eligible for this supplement (denoted with an & in table below). The second inclusive excellence initiative is a Marcus Diversity Supplement, which was awarded to all funded projects where either at least one member of the PI team is of a historically underserved background or where the project includes historically under-served people in the experimental design. We awarded 5 Diversity Supplements (denoted with ♦ in table below).
The awardees for the Marcus Program in Precision Medicine Innovation 2022 Transformative Integrated Research (TIR) Initiative are:
|
Team |
Proposal Title |
|
Prasad Shirvalkar, MD, PhD, Mark D’Esposito, MD and Edward Chang, MD (&) |
Precision Medicine for Chronic Pain: Personalized Brain Network Modulation for Chronic Neuropathic Pain Syndromes |
|
Marisa Medina, PhD and Akinyemi |
Development of a precision medicine tool to predict dysglycemic effects of statin treatment |
|
Trever Bivona, MD, PhD and Xiaokun Shu, PhD (&) |
Characterization and distinct therapeutic targeting of oncogenic protein granules |
|
Jingjing Li, PhD, David Stevenson, MD (Stanford) and Gary Shaw, DrPh (Stanford) (& and ♦ ) |
Determining Personal Genome Baselines for Progesterone Treatment of Preterm Birth |
|
Wendell Lim, PhD and Scott Zamvil, MD, PhD |
Precision Brain-Targeted Cell Therapies for Neuroinflammation |
The awardees for the Marcus Program in Precision Medicine Innovation 2022 Seeding Bold Ideas (SBI) Initiative are:
|
Team |
Proposal Title |
|
Jorge Oksenberg, PhD and Stephen Hauser, MD (& and ♦ ) |
Cell-free DNA epigenetic markers of disease progression in multiple sclerosis |
The awardees for the Marcus Program in Precision Medicine Innovation 2022 Ethics, Legal and Social Implications (ELSI) in Precision Medicine Initiative are:
|
Team |
Proposal Title |
|
Sara Ackerman, PhD, MPH and Pui-Yan Kwok, MD, PhD (&) |
Sharing Aggregate Results with Genomics Research Participants: Current Practices, Best Practices and Equity Implications |
|
Galen Joseph, PhD, Julie Harris-Wai, PhD, MPH and Mary Norton, MD (&) |
Maternal-Fetal Precision Medicine and the Practice of Genetic Counseling in the Post-Dobbs Era |
The awardees for the Marcus Program in Precision Medicine Innovation 2022 Inclusion, Diversity, Equity and Anti-Racism (IDEA) in Precision Medicine Initiative are:
|
Team |
Proposal Title |
|
John Chorba, MD and Lucas Zier, MD (& and ♦ ) |
Deep Learning of Heart Sounds to Detect Cardiovascular Disease and Improve Clinical Outcomes |
|
Dylan Chan, MD, PhD and Elliott Sherr, MD, PhD (& and ♦ ) |
Addressing Racial and Ethnic Disparities in Hearing-Loss Genetics |