Advanced Research Projects Agency for Health (ARPA-H)

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ARPA-H Current Funding Programs
ARPANET-H: A nationwide health innovation network
Helpful tips and templates
Background


As part of the first-ever White House Initiative on Women’s Health Research, First Lady Jill Biden and ARPA-H Director Renee Wegrzyn announced the ARPA-H Sprint for Women’s Health, a new funding opportunity to address unmet challenges in women’s health.

ARPA-H’s Sprint for Women’s Health will commit $100 million to fundamentally change the trajectory of women’s health care and radically accelerate the next generation of discoveries.


ARPA-H Current Funding Programs

Open Funding BAA
Abstract Due Date and Time (indicate Eastern Time): March 14, 2024

THEA

Funding BAA: Transplantation of Human Eye Allografts

  • Proposers’ Day: February 15, 2024, 9:00 AM – 5:00 PM ET in New York City, NY and virtually
  • Abstract Due Date and time: March 1, 2024, 9:00 AM EDT
  • Proposal Due Date and Time: April 15, 2024, 5:00 PM EDT

PM - Calvin Roberts, M.D.
View Opportunity Details

HEROES

Funding BAA: Health Care Rewards to Achieve Improved Outcomes

  • Hybrid Proposers’ Day: February 13-14, 2024 in Washington, D.C. and virtually
  • Anticipated Abstract Due Date: May 31, 2024
  • Anticipated Proposal Due Date: October 31, 2024PM –

Darshak Sanghavi, M.D.
View Opportunity Details

PARADIGM

Funding BAA: Platform Accelerating Rural Access to Distributed and Integrated Medical Care

  • Hybrid Proposers’ Day: week of February 12, 2024 in Phoenix, AZ and virtually
  • Anticipated Abstract Due Date: February 27, 2024, 4:00 PM ET
  • Anticipated Proposal Due Date: April 26, 2024 4:00 pm EDT

PM - Bon Ku, M.D., MPP
View Opportunity Details

APECx
Funding BAA - Antigens Predicted for Broad Viral Efficacy through Computational Experimentation

  • Abstract Due Date and time: December 1, 2023, 9:00 AM EDT
  • Proposal Due Date and Time: January 19, 2024, 5:00 PM EDT

PM - Andy Kilianski, Ph.D.
View Program Details

ARPA-H BDF Toolbox

Funding BAA: ARPA-H Biomedical Data Fabric Toolbox

  • Proposal Due Date and Time: closed

PM - Andrea Bild, Ph.D.
View Program Details

PSI

Funding BAA - Precision Surgical Interventions

  • Abstract Due Date: closed
  • Proposal Due Date and Time: closed

PM - Ileana Hancu, Ph.D.
View Program Details

DIGIHEALS

Funding BAA - Scaling Health Applications Research for Everyone (SHARE)

  • Abstract Due Date: closed
  • Proposal Due Date and Time: closed

PM - Andrew Carney
View Program Details

REACT

Funding BAA - Resilient Extended Automatic Cell Therapies

  • Abstract Due Date: closed
  • Proposal Due Date and time: closed

PM - Paul E. Sheehan, Ph.D.
View Program Details

NITRO

Novel Innovations for Tissue Regeneration in Osteoarthritis

  • Closed

PM - Ross Uhrich, DMD, MBA
View Program Details


ARPANET-H: A nationwide health innovation network

Informational Video: https://youtu.be/DbGrU0vfhdE
Spoke Membership process:
Customer Experience Hub: https://www.customerexperiencehub.org/how-to-join/
Investor Catalyst Hub: https://investorcatalysthub.org/spoke-network/ and Informational Webinar for Prospective Spokes

ARPANET-H is a nationwide health innovation network that connects people, innovators, and institutions. This network is anchored by three regional hubs — one focused on designing for the American people and their caregivers, another on catalyzing markets and industry to ensure solutions thrive after government funding, and a third hub in the National Capital Region and focused on coordinating with federal partners and managing ARPA-H’s programs.

The three hubs of ARPANET-H will lead specific focus areas, including streamlining customer experiences, catalyzing investors, and developing stakeholder and operations efforts.

  • The Customer Experience hub will focus on developing health solutions that will be accessible, needed, and readily adopted. It will take a proactive approach to diversify clinical trials, reach representative patient populations, and more leading to better and more equitable health outcomes for all. This hub’s physical location will be located in Dallas, Texas.
  • The Investor Catalyst hub will focus on speeding the transition of innovative ideas into practical, accessible solutions that deliver for Americans by engaging with researchers, entrepreneurs, and investors. This hub’s physical location will be located in Cambridge, Mass., in the greater Boston area.
  • The Stakeholder and Operations hub will be adjacent to many intergovernmental partners and stakeholders. Following a competitive review, ARPA-H will select the final site located in the National Capital Region, using federal leasing and acquisition procedures. The announcement is anticipated later in 2023.

Customer Experience

The Customer Experience consortium puts people at the center of ARPA-H programs and projects, developing technologies that will be accessible, desirable, and affordable for all. It will incorporate human centered and design-thinking principles in a variety of ways, including reaching patient populations and engaging with providers. This consortium is located in Dallas, TX and managed by our Customer Experience Hub.

Investor Catalyst

The Investor Catalyst consortium ensures that successes in research can reach the people who need them, fostering collaboration among researchers, entrepreneurs, and investors to speed the transition of innovative ideas into practical, accessible solutions. It is focused on commercializing technologies, understanding market dynamics, and providing business support to accelerate healthcare innovation. This consortium is located in the greater Boston area, MA, managed by our Investor Catalyst Hub.

Spokes Equal Reach

Hubs are responsible for persistently retaining and recruiting spokes across the United States and its territories. Spokes harness a broad range of expertise, community voices, and geographic spread. They are dynamic and change with the needs of ARPA-H programs. The network is built upon a principle of representing and including the diversity of our country, and making sure that any success resulting from an ARPA-H program can reach everyone who needs it.


Helpful tips and templates


Background

A new federal funding agency - the Advanced Research Projects Agency for Health (ARPA-H) – was created to speed medical breakthroughs to patients who urgently need them. ARPA-H is focused on a bold mission to advance high-potential, high-impact biomedical and health research that cannot be readily accomplished through traditional research or commercial activity. ARPA-H will make big bets to build high-payoff capabilities or platforms to drive biomedical breakthroughs – ranging from molecular to societal – that will provide transformative solutions for all individuals. ARPA-H will be looking for projects that are transformational, driving biomedical breakthroughs. They will not support incremental research efforts. They seek to support "Imagine if..." projects.

In September 2022, President Joe Biden appointed longtime biologist and former government scientist Renee Wegrzyn as the first director of the nascent Advanced Research Projects Agency for Health. Wegrzyn is a biomedical scientist and an entrepreneur in synthetic biology with a decade of experience leading multiple biotech projects at the Defense Advanced Research Projects Agency (DARPA). She has professional experience working for two of the institutions that inspired the creation of ARPA-H—DARPA and Intelligence Advanced Research Projects Activity (IARPA).

For the 2024 budget, Congress has provided an increase of $500 million to ARPA-H’s start-up budget of $1 billion. This new health innovation incubator, modeled after DARPA and ARPA-E, is working to jumpstart multi-sector-fueled, high-risk/high-reward science aimed at shattering barriers and forging progress against existing and emergent health threats. Importantly, the bill also includes authorizing language that will guide the next phase of this agency’s unique and important trajectory.

Research Areas and Priorities

ARPA-H will make big bets to build high-payoff capabilities or platforms to drive biomedical breakthroughs – ranging from molecular to societal – that will provide transformative solutions for all individuals. The focus areas below illustrate the types of work and impact that ARPA-H may pursue as it hires its first PMs.

Health Science Futures - Expanding what’s technically possible

Accelerating advances across research areas and removing limitations that stymie progress towards solutions. The tools and platforms developed apply to a broad range of diseases.

Scalable Solutions - Reaching everyone quickly

Addressing challenges that include geography, distribution, manufacturing, data and information, and economies of scale to create programs that result in impactful, timely, and equitable solutions.

Proactive Health - Keeping people from being patients

Reducing the likelihood that people become patients. Preventative programs will create new capabilities to detect and characterize disease risk and promote treatments and behaviors to anticipate threats to Americans’ health, whether those are viral, bacterial, chemical, physical, or psychological.

Resilient Systems - Building integrated healthcare systems

Developing capabilities, business models, and integrations to weather crises such as pandemics, social disruption, climate change, and economic instability. Resilient systems need to sustain themselves between crises – from the molecular to the societal – to better achieve outcomes that advance American health and wellbeing.

ARPA-H will be looking for projects that are transformational, driving biomedical breakthroughs. They will not support incremental research efforts. They seek to support "Imagine if..." projects. They will ask proposals to address the following set of questions about a well-defined problem.

ARPA-(H)eilmeier Questions - Towards a Well-Defined Problem
  1. What are you trying to do? What health problem are you trying to solve?
  2. How does this get done at present? Who does it? What are the limitations of present approaches?
  3. What is new about our approach? Why do we think we can be successful at this time?
  4. Who cares? If we succeed, what difference will it make?
  5. What are the risks? That may prevent you from reaching your objectives? Any risks the program itself may present?
  6. How long will it take?
  7. How much will it cost?
  8. What are our mid-term and final exams to check for success?
  9. To ensure equitable access for all people, how will cost, accessibility, and user experience be addressed?
  10. How might this program be misperceived or misused (and how can we prevent that from happening)?

ARPA-H Funding Opportunity Seminar 5/1/2023