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ARPA-H Current Funding Programs
ARPANET-H: A nationwide health innovation network
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Background

ARPA-H Current Funding Programs

Sprint for Women’s Health Initiative - submissions phase has closed.

** NEW ARPA-H Funding Mode** - Exploration Topics

No new Exploration Topics

NOTE – ARPA-H is giving less than a month from announcement to submission on these quick turn-around opportunities.

Exploration Topic (ET) Funding Opportunities

August 2024:

  • Decentralized Engineering of Cells Informed by Dynamic Evidence (DECIDE) Exploration Topic (ET). DECIDE-ET aims to advance new quality assurance technologies and accelerate the collection of evidence necessary to establish reimbursement pathways for rare disease therapies, improving access to life-changing cellular therapies, including Autologous Cell Therapy (ACT). If successful, ARPA-H believes the work in this arena would increase patients’ access to life-changing therapies from Academic Medical Centers (AMCs).
  • DECIDE is a 24-month, three-stage Exploration Topic with a single Technical Area. The three stages include: (1) method development, (2) testing and prototyping, and (3) deployment and validation. For more information, view the draft DECIDE-ET on SAM.gov.
  • Proposal due date: November 18, 2024

July 2024:

  • Predictions for Real-time Optimization of MICRObiomes of Built Environments (PRO-MICROBE) Exploration Topic to fund research on an indoor environmental quality index to monitor and predict microbial health in buildings, such as homes, hospitals, schools, and offices.
  • For more information, view the PRO-MICROBE Exploration Topic (ET) on SAM.gov. PRO-MICROBE proposals are due on November 4, 2024, 5PM ET.
  • For questions, view PRO-MICROBE ET questions and answers or submit a question on the PRO-MICROBE Solutions webpage.

April 2024:

  • Chatbot Accuracy and Reliability Evaluation (CARE) Exploration Topic (ET) to fund the development of novel technical approaches to improve the testing and evaluation of chatbot outputs for patient-facing applications.
  • See more information about CARE ETs here and see CARE Module Announcement and Q & A document for full project and submission details.

The Master Announcement Instruction (MAI) is a sort of ‘parent contract’. Specific opportunities may be solicited under the MAI at any time while the MAI remains open, currently anticipated to be 12-months from the date of release. Module Announcements will be broken into categories based on the estimated value of a potential award. See more information about MAI here.

Exploration Topic (ET) - ETs are offered under the MAI umbrella and are fast-paced efforts that pursue topics strategically aligned with ARPA-H Mission Offices and provide foundational proofs-of-concept to be used in future research. See more information about ETs here.

Mission Office-specific Innovative Solutions Openings (ISOs)

This new set of funding opportunities replaces the previous Open BAA. The “open” ideas will now be directed toward ARPA-H mission office areas (described below).

To enhance our ability to support initiatives that align with our mission and Strategic Plan, ARPA-H is now accepting submissions to its Mission Office-specific ISOs. The four Mission Office-specific ISOs include:

Focused ARPA-H Funding Programs

RAPID

BAA: Rare Disease AI/ML for Precision Integrated Diagnostics (RAPID)

  • Proposers' Day is cancelled.
  • Solution Summary Due Date and Time: February 14, 2025, 5pm ET
  • (by invitation only) Proposal Due Date and Time: April 11, 2025 5pm ET

PM - Scott Gorman, J.D., MBA

Vew Opportunity Details

PROSPR

Funding BAA: PROactive Solutions for Prolonging Resilience (PROSPR)

  • Hybrid Proposers' Day BEING RE-SCHEDULED to all virtual: January 24, 2025
    • Proposers’ Day registration deadline: being rescheduled - January 22, 2025, 12pm ET
  • Solution Summary Due Date and Time: February 10, 2025, 5pm ET
  • (by invitation only) Proposal Due Date and Time: March 24, 2025 5pm ET

PM - Andrew Brack, Ph.D.
View Opportunity Details

INDEX

Funding BAA: ImagiNg Data EXchange (INDEX)

  • Hybrid Proposers' Day held : January 7, 2025 in Seattle, WA
  • Solution Summary Due Date and Time: January 28, 2025, 5pm ET
  • (by invitation only) Proposal Due Date and Time: March 27, 2025 5pm ET

PM - Ileana Hancu, Ph.D.
View Opportunity Details

OCULAB

Funding BAA: Ocular Laboratory for Analysis of Biomarkers (OCULAB)

  • Hybrid Proposers' Day: December 12, 2024 in Tampa, FL
    • Proposers’ Day registration deadline: December 5, 2024, 12pm ET
  • Solution Summary Due Date and Time: January 27, 2025, 5pm ET
  • (by invitation only) Proposal Due Date and Time: April 14, 2025 5pm ET

PM - Calvin Roberts, M.D.
View Opportunity Details

CATALYST

Funding BAA: Computational ADME-Tox and Physiology Analysis for Safer Therapeutics (CATALYST)

  • Proposers’ Day: recording
  • Priority Solution Summary Due Date and Time: closed
  • (by invitation only) Proposal Due Date and Time: closed

PM - Andy Kilianski, Ph.D.
View Opportunity Details

PRECISE-AI

Funding BAA: Performance and Reliability Evaluation for Continuous modIfications and uSEability of AI (PRECISE-AI)

  • Proposers’ Day: October 17, 2024  (slidedeck)
  • Priority Solution Summary Due Date and Time: closed
  • (by invitation only) Proposal Due Date and Time:closed

PM - Berkman Sahiner, Ph.D.
View Opportunity Details

POSEIDON

Funding BAA: Platform Optimizing SynBio for Early Intervention and Detection in Oncology (POSEIDON)

PM - Ross Uhrich, DMD, MBA
View Opportunity Details

GLIDE

Funding BAA: Groundbreaking Lymphatic Interventions and Drug Exploration (GLIDE)

Glide Teaming page: https://arpa-h.gov/research-and-funding/programs/glide/teaming

  • Hybrid Proposers’ Day: (recording)
  • Solution Summary Due Date and Time: : closed
  • Pre-Award Pitch Due Date: TBD
  • (by invitation only) Proposal Due Date and Time: TBD

PM - Kimberley Steele, M.D., Ph.D.
View Opportunity Details

UPGRADE

Funding BAA: Universal PatchinG and Remediation for Autonomous DEfense (UPGRADE)

  • Solution Summary Due Date and Time: closed
  • (by invitation only) Proposal Due Date and Time: Closed
  • Proposers' Day slides and recording.

PM - Andrew Carney, Ph.D.
View Opportunity Details


BREATHE
Funding BAA: Building Resilient Environments for Air and Total HEalth (BREATHE)

  • Solution Summary Due Date and Time: closed
  • (by invitation only) Proposal Due Date and Time: closed

PM - Jessica Green, Ph.D.
View Opportunity Details
 

LIGHT
Funding BAA: Lymphatic Imaging, Genomics, and pHenotyping Technologies (LIGHT)

  • Solution Summary Due Date and Time: closed
  • (by invitation only) Proposal Due Date and Time: closed

PM - Kimberley Steele, M.D., Ph.D.
View Opportunity Details
 

PRINT
Funding BAA: Personalized Regenerative Immunocompetent Nanotechnology Tissue (PRINT)

  • Solution Summary Due Date and Time: closed
  • (by invitation only) Proposal Due Date and Time: closed

PM - Ryan Spitler, Ph.D.
View Opportunity Details
 

EMBODY
Funding BAA: Engineering of Immune Cells Inside the Body (EMBODY)

  • Solution Summary Due Date and Time: closed
  • (by invitation only) Proposal Due Date and Time: closed

PM - Daria Fedyukina, Ph.D.
View Opportunity Details
 

    ADAPT
    Funding BAA: ADvanced Analysis for Precision cancer Therapy

    • Proposal Due Date and Time: closed

    PM - Andrea Bild, Ph.D.
    View Opportunity Details
     

    THEA
    Funding BAA: Transplantation of Human Eye Allografts

    • Proposal Due Date and Time: Closed

    PM - Calvin Roberts, M.D.
    View Opportunity Details
     

    HEROES
    Funding BAA: Health Care Rewards to Achieve Improved Outcomes

    • Hybrid Proposers’ Day: February 13-14, 2024 in Washington, D.C. and virtually
    • Anticipated Abstract Due Date: May 31, 2024
    • Anticipated Proposal Due Date: October 31, 2024, 5:00 PM EDT

    Darshak Sanghavi, M.D.
    View Opportunity Details
     

    PARADIGM
    Funding BAA: Platform Accelerating Rural Access to Distributed and Integrated Medical Care

    • Anticipated Proposal Due Date: April 26, 2024 4:00 pm EDT

    PM - Bon Ku, M.D., MPP
    View Opportunity Details
     

    APECx
    Funding BAA - Antigens Predicted for Broad Viral Efficacy through Computational Experimentation

    • Abstract Due Date and time: closed
    • Proposal Due Date and Time: closed

    PM - Andy Kilianski, Ph.D.
    View Program Details
     

    ARPA-H BDF Toolbox
    Funding BAA: ARPA-H Biomedical Data Fabric Toolbox

    • Proposal Due Date and Time: closed

    PM - Andrea Bild, Ph.D.
    View Program Details
     

    PSI
    Funding BAA - Precision Surgical Interventions

    • Abstract Due Date: closed
    • Proposal Due Date and Time: closed

    PM - Ileana Hancu, Ph.D.
    View Program Details
     

    DIGIHEALS
    Funding BAA - Scaling Health Applications Research for Everyone (SHARE)

    • Abstract Due Date: closed
    • Proposal Due Date and Time: closed

    PM - Andrew Carney
    View Program Details
     

    REACT
    Funding BAA - Resilient Extended Automatic Cell Therapies

    • Abstract Due Date: closed
    • Proposal Due Date and time: closed

    PM - Paul E. Sheehan, Ph.D.
    View Program Details
     

    NITRO
    Novel Innovations for Tissue Regeneration in Osteoarthritis

    • Closed

    PM - Ross Uhrich, DMD, MBA
    View Program Details

    AnchorSprint for Women’s Health Initiative

    The Advanced Research Projects Agency for Health (ARPA-H) Sprint for Women’s Health aims to address critical unmet challenges in women’s health across all demographics, geographies, and socioeconomic statuses, championing transformative innovations and tackling health conditions that uniquely or disproportionately affect women from every walk of life.

    The ARPA-H Sprint for Women’s Health’s new request for solutions (RFS) funding opportunity will use two funding tracks to foster transformative research and development efforts: one for early-stage research, or “Spark” solutions, and the other for later-stage development, or “Launchpad” solutions.

    Important FAQ Update on ARPA-H Sprint for Women's Health Solution Summary submission process

    A nationwide health innovation network

    Informational Video: https://youtu.be/DbGrU0vfhdE
    Spoke Membership process:
    Customer Experience Hub: https://www.customerexperiencehub.org/how-to-join/
    Investor Catalyst Hub: https://investorcatalysthub.org/spoke-network/ and Informational Webinar for Prospective Spokes

    ARPANET-H is a nationwide health innovation network that connects people, innovators, and institutions. This network is anchored by three regional hubs — one focused on designing for the American people and their caregivers, another on catalyzing markets and industry to ensure solutions thrive after government funding, and a third hub in the National Capital Region and focused on coordinating with federal partners and managing ARPA-H’s programs.

    The three hubs of ARPANET-H will lead specific focus areas, including streamlining customer experiences, catalyzing investors, and developing stakeholder and operations efforts.

    • The Customer Experience hub will focus on developing health solutions that will be accessible, needed, and readily adopted. It will take a proactive approach to diversify clinical trials, reach representative patient populations, and more leading to better and more equitable health outcomes for all. This hub’s physical location will be located in Dallas, Texas.
    • The Investor Catalyst hub will focus on speeding the transition of innovative ideas into practical, accessible solutions that deliver for Americans by engaging with researchers, entrepreneurs, and investors. This hub’s physical location will be located in Cambridge, Mass., in the greater Boston area.
    • The Stakeholder and Operations hub will be adjacent to many intergovernmental partners and stakeholders. Following a competitive review, ARPA-H will select the final site located in the National Capital Region, using federal leasing and acquisition procedures. The announcement is anticipated later in 2023.

    Customer Experience

    The Customer Experience consortium puts people at the center of ARPA-H programs and projects, developing technologies that will be accessible, desirable, and affordable for all. It will incorporate human centered and design-thinking principles in a variety of ways, including reaching patient populations and engaging with providers. This consortium is located in Dallas, TX and managed by our Customer Experience Hub.

    Investor Catalyst

    The Investor Catalyst consortium ensures that successes in research can reach the people who need them, fostering collaboration among researchers, entrepreneurs, and investors to speed the transition of innovative ideas into practical, accessible solutions. It is focused on commercializing technologies, understanding market dynamics, and providing business support to accelerate healthcare innovation. This consortium is located in the greater Boston area, MA, managed by our Investor Catalyst Hub.

    Spokes Equal Reach

    Hubs are responsible for persistently retaining and recruiting spokes across the United States and its territories. Spokes harness a broad range of expertise, community voices, and geographic spread. They are dynamic and change with the needs of ARPA-H programs. The network is built upon a principle of representing and including the diversity of our country, and making sure that any success resulting from an ARPA-H program can reach everyone who needs it.

    Helpful tips and templates

    Background

    A new federal funding agency - the Advanced Research Projects Agency for Health (ARPA-H) – was created to speed medical breakthroughs to patients who urgently need them. ARPA-H is focused on a bold mission to advance high-potential, high-impact biomedical and health research that cannot be readily accomplished through traditional research or commercial activity. ARPA-H will make big bets to build high-payoff capabilities or platforms to drive biomedical breakthroughs – ranging from molecular to societal – that will provide transformative solutions for all individuals. ARPA-H will be looking for projects that are transformational, driving biomedical breakthroughs. They will not support incremental research efforts. They seek to support "Imagine if..." projects.

    In September 2022, President Joe Biden appointed longtime biologist and former government scientist Renee Wegrzyn as the first director of the nascent Advanced Research Projects Agency for Health. Wegrzyn is a biomedical scientist and an entrepreneur in synthetic biology with a decade of experience leading multiple biotech projects at the Defense Advanced Research Projects Agency (DARPA). She has professional experience working for two of the institutions that inspired the creation of ARPA-H—DARPA and Intelligence Advanced Research Projects Activity (IARPA).

    For the 2024 budget, Congress has provided an increase of $500 million to ARPA-H’s start-up budget of $1 billion. This new health innovation incubator, modeled after DARPA and ARPA-E, is working to jumpstart multi-sector-fueled, high-risk/high-reward science aimed at shattering barriers and forging progress against existing and emergent health threats. Importantly, the bill also includes authorizing language that will guide the next phase of this agency’s unique and important trajectory.

    Research Areas and Priorities

    ARPA-H will make big bets to build high-payoff capabilities or platforms to drive biomedical breakthroughs – ranging from molecular to societal – that will provide transformative solutions for all individuals. The focus areas below illustrate the types of work and impact that ARPA-H may pursue as it hires its first PMs.

    Health Science Futures - Expanding what’s technically possible

    Accelerating advances across research areas and removing limitations that stymie progress towards solutions. The tools and platforms developed apply to a broad range of diseases.

    Scalable Solutions - Reaching everyone quickly

    Addressing challenges that include geography, distribution, manufacturing, data and information, and economies of scale to create programs that result in impactful, timely, and equitable solutions.

    Proactive Health - Keeping people from being patients

    Reducing the likelihood that people become patients. Preventative programs will create new capabilities to detect and characterize disease risk and promote treatments and behaviors to anticipate threats to Americans’ health, whether those are viral, bacterial, chemical, physical, or psychological.

    Resilient Systems - Building integrated healthcare systems

    Developing capabilities, business models, and integrations to weather crises such as pandemics, social disruption, climate change, and economic instability. Resilient systems need to sustain themselves between crises – from the molecular to the societal – to better achieve outcomes that advance American health and wellbeing.

    ARPA-H will be looking for projects that are transformational, driving biomedical breakthroughs. They will not support incremental research efforts. They seek to support "Imagine if..." projects. They will ask proposals to address the following set of questions about a well-defined problem.

    ARPA-(H)eilmeier Questions - Towards a Well-Defined Problem
    1. What are you trying to do? What health problem are you trying to solve?
    2. How does this get done at present? Who does it? What are the limitations of present approaches?
    3. What is new about our approach? Why do we think we can be successful at this time?
    4. Who cares? If we succeed, what difference will it make?
    5. What are the risks? That may prevent you from reaching your objectives? Any risks the program itself may present?
    6. How long will it take?
    7. How much will it cost?
    8. What are our mid-term and final exams to check for success?
    9. To ensure equitable access for all people, how will cost, accessibility, and user experience be addressed?
    10. How might this program be misperceived or misused (and how can we prevent that from happening)?

    ARPA-H Funding Opportunity Seminar 5/1/2023