Marcus Program in Precision Medicine Innovation - 2018 Awardees

George and Judy Marcus Awards

Marcus Program in Precision Medicine Innovation

2018 Awardees

The Marcus Program in Precision Medicine Innovation is pleased to announce the results of the 2018 call for innovative collaborative project proposals for the Seeding Bold Ideas and Transformative Integrated Research Initiatives. We received a total of 39 excellent and potentially transformative trans-disciplinary research proposals from faculty across UCSF. 17 cross-disciplinary teams submitted proposals to the Seeding Bold Ideas (SBI) Initiative and 22 teams submitted to the Transformative Integrated Research (TIR) Initiative.

A committee of researchers representing basic, clinical, computational health, and social/behavioral sciences reviewed, discussed, and selected 7 SBI projects and 4 TIR projects for funding.

The awardees for the Marcus Program in Precision Medicine Innovation 2018 Seeding Bold Ideas (SBI) Initiative are:

Team

Proposal Title

Eric Collisson, MD
Adam Renslo, PhD

Combination Therapy Targeting Autophagy and the MEK/ERK Pathway in Pancreatic Cancer

Hannah Glass, MD, CM, MAS
Adam Numis, MD
Elliott Sherr, MD, PhD

UCSF NSR-GENE (University of California, San Francisco Neonatal Seizure Registry, GEnetics of post-Neonatal Epilepsy)

Bo Huang, PhD
Trever Bivona, MD, PhD

Oncogenic signaling by intracellular kinase protein granules

R. Katie Kelley, MD
Lawrence Fong, MD, PhD
John Gordon, MD, PhD

Hepatitis B Virus-associated mechanisms of immune escape and resistance to immunotherapy in HCC

A. Hunter Shain, PhD
Sarah Arron, MD, PhD

Mutation burden of individual keratinocytes as a biomarker to predict squamous cell carcinoma

Joseph Shieh, MD, PhD
Aleksandar Rajkovic, MD, PhD

Essential Genes and Early Disease Diagnostics

Doris Wang, MD, PhD
Coralie deHemptinne, PhD

Using chronic brain implants to understand and enhance motor learning in Parkinson's disease

The awardees for the Marcus Program in Precision Medicine Innovation 2018 Transformative Integrated Research (TIR) Initiative are:

Team

Proposal Title

Eric Collisson, MD
Jeroen Roose, PhD

Tailored, Real-­time Models of Rare Driver Mutations in Human Cancer

Robert Blelloch, MD, PhD
Lawrence Fong, MD
James Fraser, PhD

Suppression of exosome biogenesis as a means of overcoming resistance to immunocheckpoint inhibitors

Andrei Goga, MD, PhD
Sarah Knox, PhD
Patrick Ha, MD

Understanding Nerve-Tumor Cell Interactions in Oral Cancer Perineural Invasion and Metastasis

Jimmie Ye, PhD
Lindsey Criswell, MD, MPH, DSc
Jinoos Yazdany, MD, MPH

Single cell RNA and Protein Profiling to Monitor Lupus Flares and Response to Treatment